TREATMENTS LACKING IN $ 36 BN MARKET Treatment of chronic pain is still a clearly unmet medical need. There are no pain medicines which have universal efficacy and most partially effective drugs have unwanted morphine-like side effects.
Chronic pain patients frequently suffer from associated anxiety and depression which exacerbates their pain and generates a vicious cycle of low mood and increasing pain. if the DOR agonists are able to attenuate both pain and the associated affective disorders, assuming absence of toxicity and contraindications, they will have enormous market potential.
Drugs involved in U.S. OD deaths 2000–2016
Since 1999 the amount of prescription opioids sold to pharmacies, hospitals, and doctors’ offices in the USA quadrupled with no overall change in the amount of pain that Americans reported.
Deaths from prescription μ-opioids e.g. oxycodone, hydrocodone, morphine have also more than quadrupled since 1999.
Jan 2018; New York sued eight Pharma companies for fuelling the opioid crisis with conventional opioid medicines.