PROOF OF CONCEPT

NEXT: PHASE IIa READY

Therapeutic focus » The PharmNovo Journey

Safety and efficacy in patients population

HAVING FINALISED our first in man trials. Our aim is to establish efficacy through Phase IIA Proof of Concept studies in one or more patient populations starting in Q4 2026.

2026 and beyond

Human PoC and exit

  • Securing financing for onwards journey 
  • Initiation of phase IIa PoC study 
  • Expansion of patent portfolio with process- and formulation patent applications 
  • Preparations for exit with potential pharma partners 
2025

Preparing for clinical proof of concept 
Phase IIa PoC study aligned with KOLs and FDA

  • Pre-IND meeting with FDA 
  • GMP process development and manufacturing 
  • Submission and approval of CTA for phase IIa PoC study 
  • Initiation of discussions with potential pharma partners post PoC 
  • Expansion of patent portfolio with new patent applications 
2020-2024

Safety and tolerability established

  • Toxicology studies to support clinical studies
  • Clinical safety and tolerability established in Phase I 
  • Composition of matter patent granted in all major markets 
  • NIH/NIDA grant of 2.5 mEUR for preclinical investigations in opioid withdrawal syndrome (OWS) 
  • EIC award of €17.5 million in blended funding 
Until 2020

Establishment of the foundation 

  • PN6047 developed and characterised
  • Pre-clinical proof of concept  
  • Composition of matter patent applications filed in all major markets

Latest news

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August 28, 2026

New publication in The Journal of Headache and Pain

PN6047 publication in The Journal of Headache and Pain strengthens PN6047 potential in migraine and headache disorders PharmNovo is pleased to announce that new preclinical research on PN6047 has been published in The Journal of Headache and Pain, adding to the growing body of scientific evidence supporting the potential of PN6047 beyond neuropathic pain.

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June 29, 2026

Reports of broader therapeutic potential for PN6047

PharmNovo AB announces today new preclinical findings supporting the potential of PN6047 in migraine and opioid withdrawal syndrome. The findings were generated through the company's NIDA-funded collaboration with researchers at Washington University School of Medicine.

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April 17, 2026

Watch PharmNovo at LSX in Lisbon

Take the opportunity to listen to Per von Mentzer, CEO, presenting PN6047 at the LSX World Europe congress in Lisbon, March 2026. Learn how PharmNovo is shaping a new approach to pain relief with the goal to prove that powerful pain treatment doesn’t have to come with the cost of addiction. Discover how the company’s lead candidate PN6047, delivers effective pain relief without activating the mu-opioid receptor and avoiding the addiction risks associated with conventional opioids. The Phase II-ready Delta Opioid Receptor Agonist (DORA) with first-in-class potential, PN6047 represents a safer, non-addictive approach targeting a neuropathic pain market that is expected to double until 2033 and reach 13 bEUR.

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April 9, 2026

Capsules ready for Phase IIa Study

PharmNovo is pleased to announce that that the company has completed drug product manufacturing for its lead candidate PN6047. This is an important milestone as the company prepares for its upcoming Phase IIa proof-of-concept study in neuropathic pain.

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