At the forefront of PharmNovo's journey towards pioneering solutions in pain relief stands Jarkko Kalliomäki, our esteemed Chief Medical Officer since September 2022. With his profound knowledge and unwavering commitment, Jarkko brings a unique perspective to our mission.
Jarkko Kalliomäki started at PharmNovo in September 2022, taking on the role of leading clinical management. In close collaboration with Olof Breuer, Clinical Pharmacology Specialist at PharmNovo, he plays a crucial role in shaping the design and development of PharmNovo's clinical study program.
Jarkko brought his tailor-made qualities to the company at the precise moment when PharmNovo reached a critical milestone—transitioning from preclinical to clinical development.
"Upon learning about PharmNovo's project targeting delta agonists and witnessing the progress PharmNovo had achieved, I became convinced that it was the right time for me to re-enter the field of research and development. I was thrilled at the opportunity to engage in early drug development with such a highly skilled team at a dynamic, agile company."
Jarkko Kalliomäki holds an M.D. with specialities in rehabilitation medicine and pain medicine and a Ph.D. in neurophysiology. He has served as a senior consultant physician in rehabilitation medicine and pain management at several pain clinics, including Lund University Hospital, Sophiahemmet, and Capio St. Göran's Hospital, Stockholm.
Jarkko Kalliomäki also holds extensive experience in the pharmaceutical industry and has contributed to many projects related to pain management. He boasts over a decade of experience as a Senior Clinical Research Physician at AstraZeneca R&D, where he participated in several pain-related projects.
Through his years of clinical experience, Jarkko has learned that patients with neuropathic pain have significant needs and that there is a notable scarcity of effective treatments available for this condition.
"I believe I can make a significant contribution from this perspective. I also have a deep understanding of the complexity of the task and the necessity to collaborate broadly across the many competencies required to develop a novel drug for neuropathic pain successfully. Our work at PharmNovo is truly a team effort, involving both our internal and external expertise, and its success depends on the quality and commitment of our collective team effort."
What is your view on PharmNovo's potential to effectively create a safe and innovative treatment for neuropathic pain?
"Long-term pain research awaits significant breakthroughs, necessitating a deeper understanding of its underlying mechanisms, vital for innovative medications. At PharmNovo, we prioritise mechanistic understanding in our clinical programme. Our focus is on mechanical hypersensitivity, a key neuropathic pain symptom potentially applicable to other conditions. If this strategy proves successful, my experience from many years of clinical work is that it can potentially transform the lives of many people suffering from pain."
At the forefront of PharmNovo's journey towards pioneering solutions in pain relief stands Jarkko Kalliomäki, our esteemed Chief Medical Officer since September 2022. With his profound knowledge and unwavering commitment, Jarkko brings a unique perspective to our mission.
Jarkko Kalliomäki started at PharmNovo in September 2022, taking on the role of leading clinical management. In close collaboration with Olof Breuer, Clinical Pharmacology Specialist at PharmNovo, he plays a crucial role in shaping the design and development of PharmNovo's clinical study program.
Jarkko brought his tailor-made qualities to the company at the precise moment when PharmNovo reached a critical milestone—transitioning from preclinical to clinical development.
"Upon learning about PharmNovo's project targeting delta agonists and witnessing the progress PharmNovo had achieved, I became convinced that it was the right time for me to re-enter the field of research and development. I was thrilled at the opportunity to engage in early drug development with such a highly skilled team at a dynamic, agile company."
Jarkko Kalliomäki holds an M.D. with specialities in rehabilitation medicine and pain medicine and a Ph.D. in neurophysiology. He has served as a senior consultant physician in rehabilitation medicine and pain management at several pain clinics, including Lund University Hospital, Sophiahemmet, and Capio St. Göran's Hospital, Stockholm.
Jarkko Kalliomäki also holds extensive experience in the pharmaceutical industry and has contributed to many projects related to pain management. He boasts over a decade of experience as a Senior Clinical Research Physician at AstraZeneca R&D, where he participated in several pain-related projects.
Through his years of clinical experience, Jarkko has learned that patients with neuropathic pain have significant needs and that there is a notable scarcity of effective treatments available for this condition.
"I believe I can make a significant contribution from this perspective. I also have a deep understanding of the complexity of the task and the necessity to collaborate broadly across the many competencies required to develop a novel drug for neuropathic pain successfully. Our work at PharmNovo is truly a team effort, involving both our internal and external expertise, and its success depends on the quality and commitment of our collective team effort."
What is your view on PharmNovo's potential to effectively create a safe and innovative treatment for neuropathic pain?
"Long-term pain research awaits significant breakthroughs, necessitating a deeper understanding of its underlying mechanisms, vital for innovative medications. At PharmNovo, we prioritise mechanistic understanding in our clinical programme. Our focus is on mechanical hypersensitivity, a key neuropathic pain symptom potentially applicable to other conditions. If this strategy proves successful, my experience from many years of clinical work is that it can potentially transform the lives of many people suffering from pain."
The US National Institute of Drug Abuse (NIDA) has funded a project investigating the drug candidate PN6047, a novel and highly selective Delta Opioid Receptor Agonist (DORA), represents a unique approach to addressing this medical challenge.
Read moreFollowing the successful completion of our phase I study, we are pleased to announce our collaboration with WCT, Worldwide Clinical Trials, as the phase IIa study of our drug candidate PN6047. This partnership underscores our commitment to developing solutions for neuropathic pain. In the upcoming phase IIa study, PharmNovo will investigate the safety, tolerability, pharmacokinetics, and efficacy of their drug candidate PN6047 for individuals affected by neuropathic pain and experiencing Mechanical Allodynia. This distressing symptom, caused by nerve injury, often disrupts daily life and sleep. PN6047 offers a targeted approach to alleviate this condition, aiming to improve the overall pain experience. Insights on its efficacy will aid in designing subsequent phase IIb/III studies.
Read moreIn the pharmaceutical development arena, experts like Jesper Kjerulff stand out. As Global project lead and Chief operations officer (COO) of PharmNovo, Jesper Kjerulff is instrumental in propelling the company's groundbreaking project, PN6047, and advancing the field of neuropathic pain management.
Read moreIn August 2022, PharmNovo initiated the First-In-Human, (FIH), clinical study for the company’s drug candidate PN6047, aimed at evaluating its safety and tolerability. By August 2023, the study was completed, involving 104 subjects across 13 cohorts, which included both Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) cohorts. Each cohort consisted of 8 subjects, with 6 receiving active treatment and 2 receiving placebo.
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