PROJECTS IN LINE

FOCUSING ON PN6047

A woman sitting down in a test lab looking at some test tubes

Therapeutic focus » Projects

A compound with therapeutic potential

PharmNovo aims to develop novel drugs with superior clinical properties to treat patients with neuropathic pain.

Our lead compound PN6047 is a novel potent, selective and biased signalling delta opioid receptor agonist, which is predicted to reduce common symptoms of neuropathic pain and combat other conditions involving sensory hypersensitivity, including chronic cough and itch.

PharmNovo’s drug candidate PN6047 also addresses another problem: neuropathic pain patients frequently suffer from associated anxiety and depression, which exacerbates their pain and generates a vicious cycle of low mood and increasing pain.  DOR agonists can attenuate both pain and the associated emotional disorders.

In various pre-clinical studies, PN6047 has shown high selectivity and potency and very convincing efficacy in reducing neuropathic pain without any signs of the unwanted side effects of traditional opioids, such as respiratory depression, abuse potential and the development of tolerance.

PN6047 has an excellent pre-clinical safety profile and fully medicine-like properties predicting favourable dosing in humans.

PN6047 has fully drug-able properties and characteristics enabling the production of a commercial solid dosage form.

PharmNovos' current focus is on demonstrating efficacy through Phase IIA Proof of Concept studies in one or more patient populations starting in 2024.

Prior to 2020

Establishing the baseline

  • PN6047 developed
  • Convincing pre-clinical efficacy data
  • Patent applications in significant markets
2020-2023

Setting the scene

  • GMP compound production and process development
  • Toxicology studies to support clinical studies
  • Phase I and clinical target engagement studies
  • Secure patent protection in all major markets
2023-

Milestones

  • Establishing efficacy and defining  market
  • Phase IIA PoC efficacy studies in one or more patient populations
  • Identification of VC/Pharma partner
  • Alignment of path to market with regulatory authorities, in particular, EMA and FDA

Latest news

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March 21, 2024

Positive final Phase I results

The final results from the Phase I clinical for our neuropathic pain drug candidate PN6047, demonstrates safety and tolerability and a lack of the adverse effects commonly associated with conventional opioids. The findings from the Phase I trial show that PN6047 is safe and well-tolerated at the doses tested, with no serious adverse events reported.

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January 30, 2024

NIDA funds studies

The US National Institute of Drug Abuse (NIDA) has funded a project investigating the drug candidate PN6047, a novel and highly selective Delta Opioid Receptor Agonist (DORA), represents a unique approach to addressing this medical challenge.

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January 30, 2024

Meet Olof Breuer, MD, Clinical pharmacology lead

Olof Breuer's presence at PharmNovo exemplifies the company's commitment to pioneering advancements in pain relief. His visionary approach, honed through years of experience, positions him as a driving force in the quest for novel concepts in neuropathic pain relief.

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January 30, 2024

A new perspective in pain management and opioid withdrawal relief

We are proud to share an article in Dagens Industri about our groundbreaking work with PN6047. Our promising drug candidate not only has the potential to revolutionise pain relief but has also caught the attention of the National Institute on Drug Abuse (NIDA) for its role in opioid withdrawal treatment. Per von Mentzer, our CEO, states: "Our work with PN6047 could open new paths in pain relief. Particularly in neuropathic pain, our research could lead to new insights and novel treatment approaches in various clinical areas." PN6047, a selective DORA, offers a new perspective on both pain management and opioid withdrawal treatment. The results from the Phase I study show promising safety and tolerance, paving the way for further studies on its effects on opioid withdrawal syndrome.

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