With a wealth of experience in pharmaceutical development at prominent drug companies, Jesper Kjerulff is a seasoned expert who has been at the forefront of every aspect, stage, and facet of the drug development process. His international background spans the EU, the US, China, and Japan, covering regulatory approvals, in-licensing, contract negotiations, governance structures within major drug development partnerships, and the leadership of large, global, cross-functional project teams.
"I have a deep understanding of what it takes to bring a drug from concept to market, including the potential pitfalls. I believe this knowledge is of substantial value to PharmNovo," says Jesper Kjernulff.
As Chief operating officer and Project lead for PN6047, Jesper oversees the entire project. His primary focus is creating value, strategically managing risks and front-loading activities that will be valuable in the long run.
Before joining PharmNovo, Jesper Kjerulff held influential positions at Lundbeck, where he spearheaded numerous global projects. One of his accomplishments was overseeing the successful development of the antidepressant drug Brintellix®/Trintellix®, which seamlessly progressed from pre-clinical development to global registration and launch, transforming patients' lives worldwide. Jesper envisions a similar trajectory for PN6047.
"I hope and believe our drug candidate will revolutionise the treatment of neuropathic pain, set new standards, and help millions of people who suffer.".
While the realisation of this vision may be years away, Jesper has meticulously charted a roadmap. In the short term, over the next 2–3 years, PharmNovo aims to demonstrate PN6047's efficacy in reducing neuropathic pain. In the medium term, spanning 5–8 years, he believes PharmNovo, likely in collaboration with a major pharmaceutical partner, will illustrate that PN6047 fundamentally differs from conventional opioids.
"Our goal is to overcome the stigma surrounding opioids and gain approval for PN6047's use in treating neuropathic pain."
When asked about the key factors behind his belief in PN6047's success, Jesper emphasises the critical role of the team. The team, he asserts, cannot compensate for an ineffective drug, but given a potent drug, the team's expertise and dedication will be the driving force of success.
"PharmNovo's crowning achievement is assembling a team of 14 individuals, each bringing a unique blend of experience, dedication, responsibility, enthusiasm, collaboration, and competence".
As PharmNovo works to relieve the suffering of individuals with chronic pain, Jesper Kjerulff plays a vital role within the company. His objective is clear:
"I aim to make a difference. Not for personal recognition but to improve the world in a responsible way. My goal is to drive progress, solve problems, and create meaningful results".
With a wealth of experience in pharmaceutical development at prominent drug companies, Jesper Kjerulff is a seasoned expert who has been at the forefront of every aspect, stage, and facet of the drug development process. His international background spans the EU, the US, China, and Japan, covering regulatory approvals, in-licensing, contract negotiations, governance structures within major drug development partnerships, and the leadership of large, global, cross-functional project teams.
"I have a deep understanding of what it takes to bring a drug from concept to market, including the potential pitfalls. I believe this knowledge is of substantial value to PharmNovo," says Jesper Kjernulff.
As Chief operating officer and Project lead for PN6047, Jesper oversees the entire project. His primary focus is creating value, strategically managing risks and front-loading activities that will be valuable in the long run.
Before joining PharmNovo, Jesper Kjerulff held influential positions at Lundbeck, where he spearheaded numerous global projects. One of his accomplishments was overseeing the successful development of the antidepressant drug Brintellix®/Trintellix®, which seamlessly progressed from pre-clinical development to global registration and launch, transforming patients' lives worldwide. Jesper envisions a similar trajectory for PN6047.
"I hope and believe our drug candidate will revolutionise the treatment of neuropathic pain, set new standards, and help millions of people who suffer.".
While the realisation of this vision may be years away, Jesper has meticulously charted a roadmap. In the short term, over the next 2–3 years, PharmNovo aims to demonstrate PN6047's efficacy in reducing neuropathic pain. In the medium term, spanning 5–8 years, he believes PharmNovo, likely in collaboration with a major pharmaceutical partner, will illustrate that PN6047 fundamentally differs from conventional opioids.
"Our goal is to overcome the stigma surrounding opioids and gain approval for PN6047's use in treating neuropathic pain."
When asked about the key factors behind his belief in PN6047's success, Jesper emphasises the critical role of the team. The team, he asserts, cannot compensate for an ineffective drug, but given a potent drug, the team's expertise and dedication will be the driving force of success.
"PharmNovo's crowning achievement is assembling a team of 14 individuals, each bringing a unique blend of experience, dedication, responsibility, enthusiasm, collaboration, and competence".
As PharmNovo works to relieve the suffering of individuals with chronic pain, Jesper Kjerulff plays a vital role within the company. His objective is clear:
"I aim to make a difference. Not for personal recognition but to improve the world in a responsible way. My goal is to drive progress, solve problems, and create meaningful results".
The US National Institute of Drug Abuse (NIDA) has funded a project investigating the drug candidate PN6047, a novel and highly selective Delta Opioid Receptor Agonist (DORA), represents a unique approach to addressing this medical challenge.
Read moreFollowing the successful completion of our phase I study, we are pleased to announce our collaboration with WCT, Worldwide Clinical Trials, as the phase IIa study of our drug candidate PN6047. This partnership underscores our commitment to developing solutions for neuropathic pain. In the upcoming phase IIa study, PharmNovo will investigate the safety, tolerability, pharmacokinetics, and efficacy of their drug candidate PN6047 for individuals affected by neuropathic pain and experiencing Mechanical Allodynia. This distressing symptom, caused by nerve injury, often disrupts daily life and sleep. PN6047 offers a targeted approach to alleviate this condition, aiming to improve the overall pain experience. Insights on its efficacy will aid in designing subsequent phase IIb/III studies.
Read moreIn August 2022, PharmNovo initiated the First-In-Human, (FIH), clinical study for the company’s drug candidate PN6047, aimed at evaluating its safety and tolerability. By August 2023, the study was completed, involving 104 subjects across 13 cohorts, which included both Single Ascending Dose (SAD) and Multiple Ascending Dose (MAD) cohorts. Each cohort consisted of 8 subjects, with 6 receiving active treatment and 2 receiving placebo.
Read moreAt the forefront of PharmNovo's journey towards pioneering solutions in pain relief stands Jarkko Kalliomäki, our esteemed Chief Medical Officer since September 2022. With his profound knowledge and unwavering commitment, Jarkko brings a unique perspective to our mission.
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