With a wealth of experience in pharmaceutical development at prominent drug companies, Jesper Kjerulff is a seasoned expert who has been at the forefront of every aspect, stage, and facet of the drug development process. His international background spans the EU, the US, China, and Japan, covering regulatory approvals, in-licensing, contract negotiations, governance structures within major drug development partnerships, and the leadership of large, global, cross-functional project teams.
"I have a deep understanding of what it takes to bring a drug from concept to market, including the potential pitfalls. I believe this knowledge is of substantial value to PharmNovo," says Jesper Kjernulff.
As Chief operating officer and Project lead for PN6047, Jesper oversees the entire project. His primary focus is creating value, strategically managing risks and front-loading activities that will be valuable in the long run.
Before joining PharmNovo, Jesper Kjerulff held influential positions at Lundbeck, where he spearheaded numerous global projects. One of his accomplishments was overseeing the successful development of the antidepressant drug Brintellix®/Trintellix®, which seamlessly progressed from pre-clinical development to global registration and launch, transforming patients' lives worldwide. Jesper envisions a similar trajectory for PN6047.
"I hope and believe our drug candidate will revolutionise the treatment of neuropathic pain, set new standards, and help millions of people who suffer.".
While the realisation of this vision may be years away, Jesper has meticulously charted a roadmap. In the short term, over the next 2–3 years, PharmNovo aims to demonstrate PN6047's efficacy in reducing neuropathic pain. In the medium term, spanning 5–8 years, he believes PharmNovo, likely in collaboration with a major pharmaceutical partner, will illustrate that PN6047 fundamentally differs from conventional opioids.
"Our goal is to overcome the stigma surrounding opioids and gain approval for PN6047's use in treating neuropathic pain."
When asked about the key factors behind his belief in PN6047's success, Jesper emphasises the critical role of the team. The team, he asserts, cannot compensate for an ineffective drug, but given a potent drug, the team's expertise and dedication will be the driving force of success.
"PharmNovo's crowning achievement is assembling a team of 14 individuals, each bringing a unique blend of experience, dedication, responsibility, enthusiasm, collaboration, and competence".
As PharmNovo works to relieve the suffering of individuals with chronic pain, Jesper Kjerulff plays a vital role within the company. His objective is clear:
"I aim to make a difference. Not for personal recognition but to improve the world in a responsible way. My goal is to drive progress, solve problems, and create meaningful results".
With a wealth of experience in pharmaceutical development at prominent drug companies, Jesper Kjerulff is a seasoned expert who has been at the forefront of every aspect, stage, and facet of the drug development process. His international background spans the EU, the US, China, and Japan, covering regulatory approvals, in-licensing, contract negotiations, governance structures within major drug development partnerships, and the leadership of large, global, cross-functional project teams.
"I have a deep understanding of what it takes to bring a drug from concept to market, including the potential pitfalls. I believe this knowledge is of substantial value to PharmNovo," says Jesper Kjernulff.
As Chief operating officer and Project lead for PN6047, Jesper oversees the entire project. His primary focus is creating value, strategically managing risks and front-loading activities that will be valuable in the long run.
Before joining PharmNovo, Jesper Kjerulff held influential positions at Lundbeck, where he spearheaded numerous global projects. One of his accomplishments was overseeing the successful development of the antidepressant drug Brintellix®/Trintellix®, which seamlessly progressed from pre-clinical development to global registration and launch, transforming patients' lives worldwide. Jesper envisions a similar trajectory for PN6047.
"I hope and believe our drug candidate will revolutionise the treatment of neuropathic pain, set new standards, and help millions of people who suffer.".
While the realisation of this vision may be years away, Jesper has meticulously charted a roadmap. In the short term, over the next 2–3 years, PharmNovo aims to demonstrate PN6047's efficacy in reducing neuropathic pain. In the medium term, spanning 5–8 years, he believes PharmNovo, likely in collaboration with a major pharmaceutical partner, will illustrate that PN6047 fundamentally differs from conventional opioids.
"Our goal is to overcome the stigma surrounding opioids and gain approval for PN6047's use in treating neuropathic pain."
When asked about the key factors behind his belief in PN6047's success, Jesper emphasises the critical role of the team. The team, he asserts, cannot compensate for an ineffective drug, but given a potent drug, the team's expertise and dedication will be the driving force of success.
"PharmNovo's crowning achievement is assembling a team of 14 individuals, each bringing a unique blend of experience, dedication, responsibility, enthusiasm, collaboration, and competence".
As PharmNovo works to relieve the suffering of individuals with chronic pain, Jesper Kjerulff plays a vital role within the company. His objective is clear:
"I aim to make a difference. Not for personal recognition but to improve the world in a responsible way. My goal is to drive progress, solve problems, and create meaningful results".
Breaking new ground in pain management In the latest episode of BioBizBuzz, PharmNovo CEO Per von Mentzer sits down with host Mike Ward to discuss how we’re tackling one of modern medicine’s most urgent challenges: finding effective, non-addictive treatments for chronic and neuropathic pain. The conversation highlights the development of our lead candidate PN6047, a selective delta-opioid receptor agonist designed to deliver strong pain relief without the addiction risks or sedation associated with traditional opioids. Per shares insights into the scientific rationale, clinical potential, and why neuropathic pain—often caused by nerve damage from conditions like diabetes or chemotherapy—demands new thinking. For anyone interested in neuroscience, biotech innovation, or the future of pain management, this episode offers a glimpse into what could become a paradigm shift in treatment. Listen to the full episode here:
Read morePharmNovo AB is pleased to announce that the clinical trial application (CTA) for a Phase IIa proof of concept (PoC) study investigating the safety and efficacy of lead candidate PN6047 in patients with neuropathic pain has been submitted in Spain. The full title of the application is: “Randomized Double-Blind Placebo-Controlled Cross-Over Trial of the Safety, Tolerability, and Efficacy of PN6047 HCl in Peripheral Neuropathic Pain Characterized by Mechanical Allodynia.” Based on a strategic company decision, PharmNovo has submitted the CTA, in the first instance, to the Spanish Health Authorities only. Submission to the Czech Republic and Poland, the two other countries in which the trial will be conducted, is planned to take place following approval in Spain, which is expected by October 2025. Subject to additional investment, patient enrolment is expected to start by Quarter 1 2026.
Read moreTake the opportunity to listen to Per von Mentzer, CEO, presenting PN6047 at the LSX World Congress in April 2025 in London. PharmNovo is redefining pain management with PN6047, a first-in-class Delta Opioid Receptor Agonist (DORA), safer, non-addictive solution for neuropathic pain. Unlike traditional opioids, PN6047 eliminates concerns of side effects, abuse potential, and tolerance. With a proven safety profile from Phase I trials and a market projected to exceed EUR 13 billion by 2033, PN6047 is set to be a game-changer.
Read morePharmNovo has received positive and constructive feedback from the FDA for its lead drug candidate, PN6047, a selective delta opioid receptor agonist aimed at treating peripheral neuropathy with allodynia. Following a successful pre-IND meeting in January 2025, the FDA provided valuable guidance on the Phase IIa study design and had no critical comments on the CMC or non-clinical data. This paves the way for IND submission by the end of 2025 and a Phase IIa clinical trial application in Europe (Spain, Poland, Czech Republic) by Q3 2025.
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